Prognostic Value of MMP-9 -1562 C/T Gene Polymorphism in Patients With Sepsis

Prognostic Value of MMP-9 -1562 C/T Gene Polymorphism in Patients With Sepsis

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Introduction: ivoryjinelle.com Matrix metalloproteinase-9 (MMP-9) plays an important role in the pathophysiology of sepsis.A single-nucleotide polymorphism (SNP) at position -1562 (C/T) in the MMP-9 gene has been associated with differential MMP-9 expression, being higher when the -1562 T allele is present.We evaluated the association of the SNP MMP9 -1562 C/T with severity and mortality in patients with sepsis to establish whether the prognosis of the disease is affected.Materials and Methods: A case-control study exploratory was carried out in a cohort of infected patients.540 individuals were selected in total, 270 patients with sepsis and 270 controls (infected but non-septic), classified according to the 2016 consensus (Sepsis-3).

The presence of the single-nucleotide polymorphism (SNP; allele T and/or allele C) was determined through analyses of restriction fragment length polymorphism and plasma levels of MMP-9 were determined through enzyme-linked immunosorbent assay immunoassay.Results: SNP MMP-9 -1562 has two known alleles (T and C), with predominance of the C over the T allele; in the group of patients with sepsis, T allele was found in 7.2% of cases, while C allele in the rest (92.8%); in comparison, in the group of infected but non-septic patients, frequencies were 9.4% for T allele and 90.

6% for the C allele ( P =.33).Also, the presence of the polymorphic T allele was not related to the levels of MMP-9 in patients with sepsis in comparison with infected but non-septic patients 780 (397-1375) ng/mL vs 646 (172-1249) ng/mL ( P =.64).There was also no association between the SNP and sepsis mortality ( read more P =.

78).Conclusions: We concluded that there was no association between the SNP MMP9 -1562 C/T and sepsis or between the SNP MMP9 -1562 C/T and sepsis mortality in the Northeastern Colombian septic patient cohort.Further research is needed to clarify the correlation among sepsis, genetic factors with allele T and MMP-9 plasma concentration.